MADIT - Multicenter Automatic Defibrillator Implantation Trial

Status:  Completed in 1996

The clinical trial that established for the first time that patients no longer have to experience a life-threatening arrhythmia to qualify for and receive the lifesaving benefits of ICD therapy.

• Results
• Design
• Patient Population
• Clinical Relevance
• References

Results

Design

Two patient groups (1:1)
1. Conventional Medical Therapy (CMT)
2. CMT + ICD

Primary endpoint: Mortality

Patient Population

Heart attack survivors:

• Prior MI
• EF ≤ 35%
• Asymptomatic NSVT
• NYHA Class I-III

196 patients from 32 U.S. centers

• 95 received defibrillator
• 101 received medical therapy

Clinical Relevance

• Established for the first time that prophylactic ICD therapy used in conjunction with conventional medical therapy can dramatically improve survival in high-risk patients versus conventional medical therapy alone
• Patients no longer have to experience a life-threatening arrhythmia to qualify for and receive the lifesaving benefits of ICD therapy

 

References

1 - Multicenter Automatic Defibrillator Implantation Trial (MADIT): design and clinical protocol. PACE 1991, 14:920-927.

2 - Moss AJ, et al: Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med 1996, 335:1933-1940.