Inhibition of Unnecessary RV Pacing with AV Search Hysteresis in ICDs (INTRINSIC RV)

Status: Currently enrolling patients

The largest ICD trial to date investigating whether dual-chamber rate-responsive (DDDR) with Boston Scientific’s algorithm, atrioventricular search hysteresis (AVSH) 60-130 programming is not inferior to single-chamber (VVI)–40 programming in an implantable cardioverter defibrillator (ICD) with respect to all-cause mortality and heart failure hospitalizations.

 

• Results
• Design
• Patient Population
• Clinical Relevance
• References

 

Results¹

 

• Dual-chamber pacing with AV Search Hysteresis (AVSH) performed as well as single-chamber pacing (p<0.001 non-inferiority).
• Patients with dual-chamber pacing with AVSH had outcomes that trended better than patients with single-chamber pacing (p=0.072 superiority).

Design

Patient Population

• Standard ICD indications
• No indications for bradycardia pacing
• LVEF ≤ 40%
• No history of persistent atrial arrhythmias

Clinical Relevance

• Showed that dual-chamber pacing with AV Search Hysteresis performed as well as single-chamber pacing
• Represents a diverse patient population with standard ICD indications
• Perceived safety concerns were not present when appropriate dual-chamber pacing was utilized

References

¹Olshansky, B, Day, J, et al. IS Dual-Chamber Programming Inferior to Single-Chamber Programming in an Implantable Cardioverter-Defibrillator?: Results of the INTRINSIC RV (Inhibition of Unnecessary RV Pacing With AVSH in ICDs) Study. Circulation 2007:115; 13.