Heart Failure Heart Rate Variability Registry (HF-HRV)

• Results
• Design
• Patient Population
• Clinical Relevance
• References

Results

• Patients with lower HRV values had the highest mortality rate compared with patients with higher HRV values.
• Patients with low baseline HRV and small changes in HRV during the follow-up period were at the highest mortality rate.
  • 7% mortality for SDANN and 8.9% for HRV footprint
• Patients with high baseline HRV and large changes in HRV were at the lowest mortality rate.
  • 1.5% mortality for SDANN and 2.4% for HRV footprint

Design

Patient Population

1421 patients completed device implant

• Male and female patients
• Over 18 years of age
• Disease state at the time of  enrollment met indications for CRT-D therapy
• 129 sites across the United States

Clinical Relevance

HF-HRV assessed the relationships among HRV measures and NYHA Class, physical activity, and quality of life

• Continuously measured device HRV parameters may provide prognostic information about patient mortality that could be helpful for risk stratification

References

Gilliam FR, Singh JP, et al. Prognostic value of HRV footprint and standard deviation of average 5-minute intrinsic R-R intervals for mortality in CRT patients. J. Electrocard. 2007;40:336-342.

Gilliam FR, Kaplan AJ, Black J, et al. Changes in HRV, Quality of Life, and Activity in CRT Patients: Results of the HF-HRV Registry. Pacing Clin Electrophysiol. 2007;30(1):56-64.