CONTAK® CD CRT-D Study

The first study to demonstrate the benefits of CRT combined with ICD therapy, enabling a single device to treat two clinical outcomes common to patients with advanced heart failure.

• Results
• Design
• Patient Population
• Clinical Relevance
• References

Results

Patients with NYHA Class III/IV and biventricular (BiV) pacing on demonstrated improvement in:

• Peak VO2 (p = 0.003)
• 6-minute walk distance (p = 0.029)
• NYHA Class (p = 0.006)
• Quality of life (p = 0.017)

Design

Two patient groups (1:1)

• 1. BiV pacing on (CRT on)
• 2. BiV pacing off (control)

Patient Population

• NYHA Class II–IV
• LVEF ≤ 35%
• QRS ≥ 120ms
• 581 patients at 47 U.S. centers

Clinical Relevance

Combined endpoint of all-cause mortality, HF hospitalization and VT/VF requiring intervention

First study to evaluate the benefits of Cardiac Resynchronization Therapy combined with Implantable Cardioverter Defibrillator therapy, enabling a single device to treat two clinical outcomes common to patients with advanced heart failure

• Sudden Cardiac Death associated with tachyarrhythmias and worsening symptoms
• Exercise capacity due to diminished pump function

References

Higgins S, Hummel J, et al. Cardiac Resynchronization Therapy for the Treatment of Heart Failure in Patients With Intraventricular Conduction Delay and Malignant Ventricular Tachyarrhythmias. JACC 2003; 42:1454–9.